Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.58 |
| ▸ | HTR6 | P50406 | 9/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR1F | P30939 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1050312 | 0.84 | BRD4 (0.64) | BRD4HTR6METCYP2C19LMNA | |
| SCHEMBL13306682 | 0.82 | BRD4 (0.52) | BRD4HTR6METDRD2HTR7 | |
| SCHEMBL2179100 | 0.81 | BRD4 (0.54) | BRD4CYP2C19KMT2ALMNASMN1; SMN2 | |
| SCHEMBL1043519 | 0.81 | BRD4 (0.58) | BRD4HTR6METCYP2C19DRD2 | |
| SCHEMBL1887325 | 0.81 | BRD4 (0.58) | BRD4HTR6METCYP2C19DRD2 | |
| SCHEMBL1773252 | 0.81 | BRD4 (0.58) | BRD4HTR6METCYP2C19DRD2 | |
| SCHEMBL1266871 | 0.81 | BRD4 (0.58) | BRD4HTR6METCYP2C19DRD2 | |
| SCHEMBL1799967 | 0.81 | BRD4 (0.67) | BRD4HTR6METCYP2C19 | |
| SCHEMBL1268099 | 0.81 | BRD4 (0.58) | BRD4HTR6DRD2HTR7HTR2A | |
| SCHEMBL1082937 | 0.79 | BRD4 (0.54) | BRD4HTR6MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |