Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1849203 | 0.86 | ALDH1A3 (0.52) | ALDH1A3ALDH1A1ERN1KMT2APPARG | |
| SCHEMBL1121444 | 0.86 | ALDH1A3 (0.63) | ALDH1A3ALDH1A1ERN1KMT2APPARG | |
| SCHEMBL12037831 | 0.82 | ALDH1A3 (0.63) | ALDH1A3ALDH1A1ERN1KMT2ABRD4 | |
| SCHEMBL10210016 | 0.82 | SRC (0.36) | ALDH1A1KMT2ASRC | |
| SCHEMBL20881111 | 0.80 | ALDH1A3 (0.49) | ALDH1A3ALDH1A1ERN1KMT2APPARG | |
| SCHEMBL22779349 | 0.79 | ALDH1A3 (0.55) | ALDH1A3ALDH1A1ERN1KMT2A | |
| SCHEMBL1748564 | 0.79 | ALDH1A3 (0.55) | ALDH1A3ALDH1A1ERN1KMT2APARP10 | |
| SCHEMBL14018645 | 0.75 | ALDH1A3 (0.55) | ALDH1A3ALDH1A1ERN1KMT2ASRC | |
| SCHEMBL5882247 | 0.75 | ALDH1A3 (0.50) | ALDH1A3ALDH1A1PPARGPPARDPPARA | |
| SCHEMBL12038129 | 0.74 | ALDH1A3 (0.53) | ALDH1A3ALDH1A1ERN1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |