Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 12/20 | 0.75 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13307444 | 0.86 | PDPK1 (0.85) | PDPK1BRD4PDE10AFSCN1MAPT | |
| SCHEMBL19787938 | 0.85 | PDPK1 (1.00) | PDPK1BRD4PDE10AFSCN1GAA | |
| SCHEMBL13307439 | 0.85 | PDPK1 (0.83) | PDPK1BRD4PDE10AFSCN1 | |
| SCHEMBL13307445 | 0.85 | PDPK1 (0.83) | PDPK1BRD4 | |
| SCHEMBL13333000 | 0.84 | PDPK1 (0.79) | PDPK1BRD4PDE10AFSCN1MAPT | |
| SCHEMBL13307447 | 0.83 | PDPK1 (1.00) | PDPK1MAPT | |
| SCHEMBL13307442 | 0.83 | PDPK1 (1.00) | PDPK1BRD4GAALMNAMAPT | |
| SCHEMBL13307450 | 0.81 | PDPK1 (0.83) | PDPK1 | |
| SCHEMBL13306406 | 0.81 | PDPK1 (1.00) | PDPK1MAPT | |
| SCHEMBL13307440 | 0.79 | PDPK1 (0.83) | PDPK1BRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |