Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 11/20 | 0.83 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13307444 | 0.94 | PDPK1 (0.85) | PDPK1BRD4KLKB1 | |
| SCHEMBL13307442 | 0.91 | PDPK1 (1.00) | PDPK1BRD4KLKB1 | |
| SCHEMBL13333000 | 0.87 | PDPK1 (0.79) | PDPK1BRD4KLKB1 | |
| SCHEMBL19787940 | 0.85 | PDPK1 (0.75) | PDPK1BRD4 | |
| SCHEMBL13306406 | 0.85 | PDPK1 (1.00) | PDPK1 | |
| SCHEMBL13307439 | 0.83 | PDPK1 (0.83) | PDPK1BRD4 | |
| SCHEMBL19787937 | 0.82 | PDPK1 (0.67) | PDPK1ADRA1D | |
| SCHEMBL13307448 | 0.82 | PDPK1 (0.94) | PDPK1 | |
| SCHEMBL13307437 | 0.81 | PDPK1 (1.00) | PDPK1KLKB1 | |
| SCHEMBL13306532 | 0.80 | PDPK1 (0.82) | PDPK1ADRA1DBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778977-B2 | Pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778977-B2 | Pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20100144730-A1 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHAMACEUTICALS (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100144730-A1 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHAMACEUTICALS (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144730-A1 | PYRIDINONYL PDK1 INHIBITORS | PDK1, PDK2, PDK3 | PDPK1 5/4885ADRA1D 4492/4885BRD4 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.