Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10243854 | 0.84 | ALDH1A1 (0.61) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL23142607 | 0.84 | ALDH1A1 (0.61) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL2847154 | 0.83 | ALDH1A1 (0.59) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL13688689 | 0.83 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL6449232 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL7269037 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL4178623 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL111840 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL27928375 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL19718289 | 0.81 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969728-B2 | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2018-05-15 | — | — | US | disclosed |
| US-9932342-B2 | Imidazopyrimidine derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2018-04-03 | — | — | US | disclosed |
| US-9873703-B2 | Imidazopyridazine derivatives as modulators of TNF activity | UCB BIOPHARMA SPRL (BE) | 2018-01-23 | — | — | US | disclosed |