Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.66 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 2/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19688107 | 0.93 | MME (0.59) | MMEPSMB8ACE | |
| SCHEMBL18922289 | 0.93 | MME (0.59) | MMEPSMB8ACE | |
| SCHEMBL19688112 | 0.92 | MME (0.67) | MMEPSMB8ACESMPD1 | |
| SCHEMBL15467928 | 0.92 | MME (0.67) | MMEPSMB8ACESMPD1 | |
| SCHEMBL19788121 | 0.90 | MME (0.52) | MMEACE | |
| SCHEMBL18922291 | 0.86 | MME (0.56) | MMEACE | |
| SCHEMBL19688110 | 0.86 | MME (0.56) | MMEACE | |
| SCHEMBL19687853 | 0.86 | MME (0.59) | MMEACE | |
| SCHEMBL21350796 | 0.86 | MME (0.59) | MMEACE | |
| SCHEMBL21351161 | 0.85 | MME (0.60) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570120-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2020-02-25 | — | — | US | disclosed |
| US-20190276442-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2019-09-12 | — | — | US | disclosed |
| US-9873685-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190276442-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | MME 1/4885PSMB8 531/4885ACE 3/4885 |
| US-10570120-B2 | Neprilysin inhibitors | MME, REN, ACE | MME 1/4885PSMB8 531/4885ACE 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.