Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.51 |
| ▸ | ACE | P12821 | 4/20 | 0.48 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19787720 | 0.92 | MME (0.52) | MMEACEMMEL1 | |
| SCHEMBL19788048 | 0.91 | MME (0.51) | MMEACEMMEL1 | |
| SCHEMBL19788111 | 0.90 | MME (0.52) | MMEACEMMEL1 | |
| SCHEMBL19788049 | 0.89 | MME (0.54) | MMEACEMMEL1 | |
| SCHEMBL19788092 | 0.86 | MME (0.51) | MMEACE | |
| SCHEMBL15202178 | 0.86 | MME (0.66) | MMEACEMMEL1 | |
| SCHEMBL11969744 | 0.86 | MME (0.66) | MMEACEMMEL1 | |
| SCHEMBL22414088 | 0.85 | MME (0.53) | MMEACEMMEL1 | |
| SCHEMBL18922342 | 0.85 | MME (0.53) | MMEACEMMEL1 | |
| SCHEMBL19787719 | 0.84 | MME (0.52) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873685-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-01-23 | — | — | US | disclosed |