Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CTH | P32929 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TCF4 | P15884 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16848014 | 1.00 | EGFR (0.47) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL22564644 | 0.91 | EGFR (0.45) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL23022615 | 0.91 | EGFR (0.48) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL13444092 | 0.91 | EGFR (0.48) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL8171745 | 0.91 | EGFR (0.48) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL23022613 | 0.89 | ELANE (0.47) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL25823938 | 0.88 | EGFR (0.46) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL23022621 | 0.88 | EGFR (0.46) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL18909514 | 0.88 | ELANE (0.42) | EGFRPIM1ELANEMEN1KMT2A | |
| SCHEMBL22873368 | 0.87 | EGFR (0.51) | EGFRPIM1ELANEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020219748-A2 | ANTI-CD117 ANTIBODIES AND USES THEREOF | Magenta Therapeutics, Inc. (US) | 2020-10-29 | — | — | WO | disclosed |
| WO-2020219770-A1 | ANTI-CD117 ANTIBODIES AND USES THEREOF | Magenta Therapeutics, Inc. (US) | 2020-10-29 | — | — | WO | disclosed |
| WO-2020146432-A1 | USE OF AN ANTI-CD45 ANTIBODY DRUG CONJUGATE (ADC) IN CELL THERAPY | Magenta Therapeutics, Inc. (US) | 2020-07-16 | — | — | WO | disclosed |
| EP-2673004-B1 | HYDROPHOBIC MODIFIED PEPTIDES AND THEIR USE FOR LIVER SPECIFIC TARGETING | Ruprecht-Karls-Universität Heidelberg (DE) | 2018-01-24 | — | — | EP | disclosed |