Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 8/20 | 0.69 |
| ▸ | PSMB11 | A5LHX3 | 7/20 | 0.69 |
| ▸ | PSMA7 | O14818 | 7/20 | 0.69 |
| ▸ | PSMB1 | P20618 | 7/20 | 0.69 |
| ▸ | PSMA1 | P25786 | 7/20 | 0.69 |
| ▸ | PSMA2 | P25787 | 7/20 | 0.69 |
| ▸ | PSMA3 | P25788 | 7/20 | 0.69 |
| ▸ | PSMA4 | P25789 | 7/20 | 0.69 |
| ▸ | PSMB8 | P28062 | 7/20 | 0.69 |
| ▸ | PSMB9 | P28065 | 7/20 | 0.69 |
| ▸ | PSMA5 | P28066 | 7/20 | 0.69 |
| ▸ | PSMB4 | P28070 | 7/20 | 0.69 |
| ▸ | PSMB6 | P28072 | 7/20 | 0.69 |
| ▸ | PSMB10 | P40306 | 7/20 | 0.69 |
| ▸ | PSMB3 | P49720 | 7/20 | 0.69 |
| ▸ | PSMB2 | P49721 | 7/20 | 0.69 |
| ▸ | PSMA6 | P60900 | 7/20 | 0.69 |
| ▸ | PSMA8 | Q8TAA3 | 7/20 | 0.69 |
| ▸ | PSMB7 | Q99436 | 7/20 | 0.69 |
| ▸ | LONP1 | P36776 | 12/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10344951 | 0.81 | PSMB5 (1.00) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL18175253 | 0.80 | PSMB5 (0.95) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL30447782 | 0.78 | PSMB5 (0.73) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL25218642 | 0.78 | PSMB5 (0.73) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL25268846 | 0.78 | PSMB5 (0.73) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL25268847 | 0.78 | PSMB5 (0.73) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL2506640 | 0.75 | LONP1 (0.91) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL3139040 | 0.75 | LONP1 (0.67) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL3139055 | 0.75 | LONP1 (0.67) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL8186108 | 0.74 | PSMB11 (0.50) | PSMB5PSMB11PSMA7PSMB1PSMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552216-B1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARM INC (US) | 2018-01-24 | — | — | EP | disclosed |