Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 14/20 | 1.00 |
| ▸ | PSMB11 | A5LHX3 | 10/20 | 1.00 |
| ▸ | PSMA7 | O14818 | 10/20 | 1.00 |
| ▸ | PSMB1 | P20618 | 10/20 | 1.00 |
| ▸ | PSMA1 | P25786 | 10/20 | 1.00 |
| ▸ | PSMA2 | P25787 | 10/20 | 1.00 |
| ▸ | PSMA3 | P25788 | 10/20 | 1.00 |
| ▸ | PSMA4 | P25789 | 10/20 | 1.00 |
| ▸ | PSMB8 | P28062 | 10/20 | 1.00 |
| ▸ | PSMB9 | P28065 | 10/20 | 1.00 |
| ▸ | PSMA5 | P28066 | 10/20 | 1.00 |
| ▸ | PSMB4 | P28070 | 10/20 | 1.00 |
| ▸ | PSMB6 | P28072 | 10/20 | 1.00 |
| ▸ | PSMB10 | P40306 | 10/20 | 1.00 |
| ▸ | PSMB3 | P49720 | 10/20 | 1.00 |
| ▸ | PSMB2 | P49721 | 10/20 | 1.00 |
| ▸ | PSMA6 | P60900 | 10/20 | 1.00 |
| ▸ | PSMA8 | Q8TAA3 | 10/20 | 1.00 |
| ▸ | PSMB7 | Q99436 | 10/20 | 1.00 |
| ▸ | LONP1 | P36776 | 12/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18175253 | 0.98 | PSMB5 (0.95) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL18175249 | 0.91 | PSMB5 (0.84) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL12340819 | 0.88 | PSMB5 (0.79) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL12340816 | 0.88 | PSMB5 (0.79) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL21759005 | 0.85 | PSMB5 (0.74) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL18175252 | 0.84 | PSMB5 (0.83) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL22787115 | 0.82 | LONP1 (1.00) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL21210367 | 0.82 | LONP1 (1.00) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL15699269 | 0.82 | LONP1 (1.00) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL19790164 | 0.81 | PSMB5 (0.69) | PSMB5PSMB11PSMA7PSMB1PSMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160250237-A1 | SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF | BACH BIOSCIENCES, LLC | 2016-09-01 | — | — | US | disclosed |
| US-9192646-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-11-24 | — | — | US | disclosed |
| US-20150157684-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | BACH BIOSCIENCES, LLC | 2015-06-11 | — | — | US | disclosed |
| US-8933056-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140128344-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2014-05-08 | — | — | US | disclosed |
| US-8563533-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-10-22 | — | — | US | disclosed |
| US-8268880-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268880-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2012-09-18 | — | — | US | disclosed |
| WO-2012096919-A1 | COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH PROTEASOME INHIBITORS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-07-19 | — | — | WO | disclosed |
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE OFFICE OF TECHNOLOGY AND INDUSTRY COLLABORATION (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE OFFICE OF TECHNOLOGY AND INDUSTRY COLLABORATION (US) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | PSMB5 142/4885PSMB11 223/4885PSMA7 165/4885 |
| US-20160250237-A1 | SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF | PREP, DPP4, PEPD | PSMB5 142/4885PSMB11 223/4885PSMA7 165/4885 |
| US-20150157684-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | PSMB5 142/4885PSMB11 223/4885PSMA7 165/4885 |
| US-20140128344-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | PSMB5 142/4885PSMB11 223/4885PSMA7 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.