Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 13/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25892734 | 0.88 | AKR1B1 (0.63) | AKR1B1PBRM1AKR1B10AKR1A1 | |
| SCHEMBL1821671 | 0.81 | ALOX12 (0.39) | AKR1B1AKR1B10AKR1A1BACE1 | |
| SCHEMBL1820144 | 0.81 | BACE1 (0.39) | AKR1B1AKR1B10AKR1A1BACE1 | |
| SCHEMBL1824927 | 0.80 | AKR1B1 (0.37) | AKR1B1AKR1B10AKR1A1BACE1 | |
| SCHEMBL1824168 | 0.80 | AKR1B1 (0.43) | AKR1B1AKR1B10AKR1A1BACE1 | |
| SCHEMBL7957154 | 0.80 | SIRT2 (0.35) | AKR1B1AKR1B10AKR1A1BACE1 | |
| SCHEMBL1825508 | 0.78 | MAPT (0.34) | AKR1B1AKR1B10AKR1A1BACE1 | |
| SCHEMBL1820450 | 0.78 | AKR1B1 (0.38) | AKR1B1AKR1B10AKR1A1BACE1 | |
| SCHEMBL2377131 | 0.78 | BACE1 (0.54) | AKR1B1AKR1B10AKR1A1BACE1 | |
| SCHEMBL7948443 | 0.78 | BACE1 (0.37) | AKR1B1PBRM1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |