Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 13/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19791302 | 0.80 | BACE1 (0.43) | BACE1BACE2 | |
| SCHEMBL19791259 | 0.79 | BACE1 (0.45) | BACE1CTSDBACE2 | |
| SCHEMBL19791144 | 0.77 | BACE1 (0.39) | BACE1CTSDBACE2 | |
| SCHEMBL17260317 | 0.76 | BACE1 (0.72) | BACE1ATMKCNH2DHFR | |
| SCHEMBL15839677 | 0.76 | BACE1 (0.72) | BACE1ATMKCNH2DHFR | |
| SCHEMBL15839682 | 0.75 | BACE1 (0.58) | BACE1KCNH2DHFRCTSDBACE2 | |
| SCHEMBL17260330 | 0.75 | BACE1 (0.58) | BACE1KCNH2DHFRCTSDBACE2 | |
| SCHEMBL19791307 | 0.75 | BACE1 (0.37) | BACE1CTSDBACE2 | |
| Hydrochloric Acid SCHEMBL9054384 | 0.74 | NOS2 (0.51) | BACE1KCNH2 | |
| SCHEMBL15826169 | 0.73 | BACE1 (0.68) | BACE1CYP2A6MEN1PSIP1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935256-B1 | 4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL MYERS SQUIBB CO (US) | 2018-01-24 | — | — | EP | disclosed |