Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14165303 | 0.86 | BACE2 (0.44) | BACE2BACE1MAPTHTT | |
| SCHEMBL1979221 | 0.86 | BACE2 (0.44) | BACE2BACE1MAPTHTT | |
| SCHEMBL1984301 | 0.82 | CYP2D6 (0.33) | CYP2D6 | |
| SCHEMBL1979567 | 0.80 | BACE2 (0.42) | BACE2BACE1MAPTHTT | |
| SCHEMBL13268504 | 0.79 | BACE1 (0.32) | BACE1CYP2D6 | |
| SCHEMBL13859149 | 0.78 | MAPK1 (0.33) | MAPTHTT | |
| SCHEMBL13859030 | 0.77 | SMN1; SMN2 (0.33) | BACE2BACE1MAPTHTT | |
| SCHEMBL13859233 | 0.76 | MAPT (0.43) | BACE2BACE1MAPTPOLBHTT | |
| SCHEMBL13278685 | 0.76 | BACE2 (0.44) | BACE2BACE1MAPTHTT | |
| SCHEMBL1979936 | 0.74 | BACE1 (0.44) | BACE2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509965-A1 | 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011069934-A1 | 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |