Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979221 | 0.81 | BACE2 (0.44) | MAPTLMNAHTTALDH1A1HIF1A | |
| SCHEMBL14165303 | 0.81 | BACE2 (0.44) | MAPTLMNAHTTALDH1A1HIF1A | |
| SCHEMBL13859149 | 0.78 | MAPK1 (0.33) | MAPTLMNAHTTALDH1A1HIF1A | |
| SCHEMBL13859030 | 0.77 | SMN1; SMN2 (0.33) | MAPTLMNAHTTALDH1A1CYP1A2 | |
| SCHEMBL1979176 | 0.76 | BACE2 (0.33) | MAPTHTTCYP2D6BACE2BACE1 | |
| SCHEMBL13836514 | 0.75 | LMNA (0.53) | MAPTLMNAHTTBACE2BACE1 | |
| SCHEMBL13836515 | 0.75 | LMNA (0.53) | MAPTLMNAHTTBACE2BACE1 | |
| SCHEMBL13278685 | 0.74 | BACE2 (0.44) | MAPTLMNAHTTALDH1A1HIF1A | |
| SCHEMBL1980524 | 0.73 | NPY5R (0.33) | ALDH1A1CYP2D6NPY5R | |
| SCHEMBL1979567 | 0.73 | BACE2 (0.42) | MAPTLMNAHTTALDH1A1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709992-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156284-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-22 | — | — | WO | disclosed |