Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18508381 | 0.93 | KDM4E (0.44) | EPHX1KDM4EPOLBTHRBTDP1 | |
| SCHEMBL18551479 | 0.93 | EPHX1 (0.52) | EPHX1KDM4EPOLBTHRBTDP1 | |
| SCHEMBL19978005 | 0.91 | — | — | |
| SCHEMBL18551481 | 0.89 | EPHX1 (0.48) | EPHX1KDM4EPOLBTHRBTDP1 | |
| SCHEMBL18508380 | 0.89 | KDM4E (0.44) | EPHX1KDM4EPOLBTHRBTDP1 | |
| SCHEMBL21634542 | 0.89 | EPHX1 (0.48) | EPHX1KDM4EPOLBTHRBTDP1 | |
| SCHEMBL20710373 | 0.89 | ALDH1A1 (0.48) | KDM4EPOLBTHRBTDP1ALDH1A1 | |
| SCHEMBL19977997 | 0.86 | EPHX1 (0.44) | EPHX1KDM4EPOLBTHRBTDP1 | |
| SCHEMBL5933472 | 0.86 | ALDH1A1 (0.46) | KDM4EPOLBTHRBTDP1ALDH1A1 | |
| SCHEMBL19861543 | 0.84 | ALDH1A1 (0.59) | EPHX1KDM4EPOLBTHRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3272749-A1 | AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | Bayer Pharma Aktiengesellschaft (DE) | 2018-01-24 | — | — | EP | disclosed |