Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19792181 | 1.00 | HSD17B10 (0.34) | HSD17B10LMNANPSR1EPHX2CHRM2 | |
| SCHEMBL935289 | 0.87 | NR1H2 (0.34) | HSD17B10EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL935288 | 0.87 | NR1H2 (0.34) | HSD17B10EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL26782806 | 0.87 | NR1H2 (0.34) | HSD17B10EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL25234631 | 0.78 | CHRM2 (0.39) | HSD17B10EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL19792176 | 0.78 | ACACB (0.40) | HSD17B10EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL16800261 | 0.78 | ACACB (0.40) | HSD17B10EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL20404152 | 0.77 | HSD17B10 (0.35) | HSD17B10LMNANPSR1EPHX2KDM1A | |
| SCHEMBL204377 | 0.76 | HSD17B10 (0.41) | HSD17B10LMNANPSR1EPHX2CHRM2 | |
| SCHEMBL20811615 | 0.76 | HSD17B10 (0.41) | HSD17B10LMNANPSR1EPHX2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3272747-A1 | METHOD OF PREPARATION FOR LEDIPASVIR AND DERIVATIVE THEREOF, AND INTERMEDIATE COMPOUND FOR PREPARATION OF LEDIPASVIR | Shanghai Forefront Pharmceutical Co., Ltd (CN) | 2018-01-24 | — | — | EP | disclosed |