Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15229449 | 0.87 | EPHX2 (0.35) | HSD17B10EPHX2NR1H2RXRANR1H3 | |
| SCHEMBL22838030 | 0.86 | HSD17B10 (0.34) | HSD17B10EPHX2NR1H2RXRANR1H3 | |
| SCHEMBL24529327 | 0.83 | NR1H2 (0.34) | HSD17B10EPHX2NR1H2RXRANR1H3 | |
| SCHEMBL15054838 | 0.80 | EPHX2 (0.37) | HSD17B10EPHX2KDM1ASMN1; SMN2USP2 | |
| SCHEMBL16352853 | 0.79 | EPHX2 (0.35) | HSD17B10EPHX2NR1H2RXRANR1H3 | |
| SCHEMBL26151530 | 0.78 | EPHX2 (0.36) | HSD17B10EPHX2NR1H2RXRANR1H3 | |
| SCHEMBL27181462 | 0.78 | — | — | |
| SCHEMBL24529328 | 0.78 | — | — | |
| SCHEMBL10215488 | 0.77 | HSD17B10 (0.39) | HSD17B10EPHX2LMNANPSR1KDM1A | |
| SCHEMBL19792181 | 0.77 | HSD17B10 (0.34) | HSD17B10EPHX2LMNANPSR1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3427738-B1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA (US) | 2021-12-01 | — | — | EP | disclosed |
| EP-3427738-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Incorporated (US) | 2019-01-16 | — | — | EP | disclosed |
| EP-3141252-B1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA (US) | 2018-07-25 | — | — | EP | disclosed |