Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978652 | 0.87 | SIRT2 (0.38) | ALDH1A1GAATHRBHTTL3MBTL1 | |
| SCHEMBL1979605 | 0.85 | BACE1 (0.32) | BACE2BACE1 | |
| SCHEMBL1993274 | 0.79 | SIRT2 (0.38) | ALDH1A1GAATHRBHTTL3MBTL1 | |
| SCHEMBL1442050 | 0.79 | ALDH1A1 (0.40) | ALDH1A1GAATHRBHTTL3MBTL1 | |
| SCHEMBL1976755 | 0.79 | ALDH1A1 (0.40) | ALDH1A1GAATHRBHTTL3MBTL1 | |
| SCHEMBL1976754 | 0.79 | ALDH1A1 (0.40) | ALDH1A1GAATHRBHTTL3MBTL1 | |
| SCHEMBL1978685 | 0.77 | BACE2 (0.44) | ALDH1A1GAATHRBHTTL3MBTL1 | |
| SCHEMBL1977137 | 0.76 | BACE1 (0.41) | ALDH1A1GAATHRBHTTL3MBTL1 | |
| SCHEMBL1977139 | 0.76 | BACE1 (0.41) | ALDH1A1GAATHRBHTTL3MBTL1 | |
| SCHEMBL1975801 | 0.74 | BACE1 (0.41) | ALDH1A1GAATHRBHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509966-A1 | AMINO OXAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011070029-A1 | AMINO OXAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |