Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.49 |
| ▸ | ATR | Q13535 | 6/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12598113 | 1.00 | TLR9 (0.49) | TLR9TLR7TLR8ATRJAK2 | |
| SCHEMBL12597821 | 0.96 | TLR9 (0.44) | TLR9TLR7TLR8ATRJAK2 | |
| SCHEMBL12597443 | 0.88 | TLR9 (0.44) | TLR9TLR7TLR8PIM1ABL1 | |
| SCHEMBL12597826 | 0.88 | TLR9 (0.43) | TLR9TLR7TLR8PIM1ABL1 | |
| SCHEMBL1979090 | 0.86 | ABL1 (0.47) | TLR9TLR7TLR8ABL1BCR | |
| SCHEMBL1980375 | 0.85 | JAK2 (0.45) | TLR9TLR7TLR8JAK2JAK1 | |
| SCHEMBL1979494 | 0.85 | DYRK1A (0.46) | TLR9TLR7TLR8CDK1CDK4 | |
| SCHEMBL12597824 | 0.85 | TLR8 (0.41) | TLR9TLR7TLR8PIM1ABL1 | |
| SCHEMBL11929481 | 0.84 | ATR (0.47) | ATRCDK1CDK4CCNB1CCND1 | |
| SCHEMBL11929488 | 0.84 | ATR (0.47) | ATRCDK1CDK4CCNB1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |