Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12597822 | 0.86 | TLR9 (0.37) | DYRK1ATLR9TLR8TLR7PIM1 | |
| SCHEMBL1979506 | 0.85 | TLR9 (0.49) | TLR9TLR8TLR7PIM1CDK1 | |
| SCHEMBL12598113 | 0.85 | TLR9 (0.49) | TLR9TLR8TLR7PIM1CDK1 | |
| SCHEMBL473656 | 0.84 | DYRK1A (0.46) | DYRK1AMCHR1TLR9TLR8TLR7 | |
| SCHEMBL1978545 | 0.83 | IGF1R (0.41) | DYRK1ATLR7PIM1IGF1R | |
| SCHEMBL12597443 | 0.83 | TLR9 (0.44) | TLR9TLR8TLR7PIM1 | |
| SCHEMBL12597621 | 0.83 | TLR9 (0.41) | TLR9TLR8TLR7PIM1 | |
| SCHEMBL12597821 | 0.82 | TLR9 (0.44) | TLR9TLR8TLR7PIM1CDK1 | |
| SCHEMBL12597820 | 0.82 | TLR9 (0.40) | DYRK1AMCHR1TLR9TLR8TLR7 | |
| SCHEMBL1979090 | 0.82 | ABL1 (0.47) | TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |