Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 8/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12540671 | 0.89 | AAK1 (0.48) | AAK1NR3C2GAKHTR2BDAPK1 | |
| SCHEMBL1979750 | 0.84 | RAB9A (0.46) | AAK1NR3C2HCKMAPK14MAPK12 | |
| SCHEMBL1979745 | 0.84 | RAB9A (0.46) | AAK1NR3C2HCKMAPK14MAPK12 | |
| SCHEMBL2311222 | 0.81 | NR3C2 (0.49) | AAK1NR3C2HCKMAPK14MAPK12 | |
| SCHEMBL2471852 | 0.80 | AAK1 (0.38) | AAK1NR3C2HCKMAPK14MAPK12 | |
| SCHEMBL1979137 | 0.78 | NR3C2 (0.51) | NR3C2HCKMAPK14MAPK12 | |
| SCHEMBL1980300 | 0.77 | NR3C2 (0.43) | AAK1NR3C2HCKMAPK14MAPK12 | |
| SCHEMBL13331029 | 0.77 | GCK (0.49) | HCKMAPK14MAPK12SRC | |
| SCHEMBL1981716 | 0.75 | NR3C2 (0.50) | AAK1NR3C2HCKMAPK14MAPK12 | |
| SCHEMBL2531112 | 0.75 | MAPK14 (0.73) | HCKMAPK14MAPK12SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509595-A1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | Respivert Limited (GB) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011070368-A1 | ANTIVIRAL USE OF UREA COMPOUNDS | RESPIVERT LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070369-A1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | RESPIVERT LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |