Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18012041 | 0.95 | IDH1 (0.41) | IDH1P2RX7PDE5AGNRHRFFAR2 | |
| SCHEMBL18011958 | 0.88 | PDE5A (0.38) | IDH1P2RX7PDE5AGNRHRFFAR2 | |
| SCHEMBL19795839 | 0.87 | PDE5A (0.37) | IDH1P2RX7PDE5ASLC6A2SLC6A4 | |
| SCHEMBL18012011 | 0.79 | CYP19A1 (0.43) | IDH1GNRHRSMN1; SMN2LMNA | |
| SCHEMBL19795850 | 0.77 | CYP19A1 (0.40) | IDH1SLC6A2SLC6A4SLC6A3GNRHR | |
| SCHEMBL18011887 | 0.77 | MAPK1 (0.44) | SMN1; SMN2LMNA | |
| SCHEMBL19795849 | 0.75 | MAPK1 (0.41) | SMN1; SMN2LMNA | |
| SCHEMBL18011728 | 0.75 | CYP19A1 (0.36) | CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL19795842 | 0.75 | ALDH1A1 (0.34) | IDH1NPSR1SMN1; SMN2POLBLMNA | |
| SCHEMBL19795851 | 0.75 | HPGD (0.37) | SLC6A2SLC6A4SLC6A3GNRHRFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180022697-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV MICHIGAN REGENTS (US) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022697-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | GBA1, GBA2, GAA | IDH1 849/4885P2RX7 4517/4885PDE5A 1470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.