Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347958 | 0.89 | CHKA (0.62) | CHKAHDAC6TSHRHRH3RAB9A | |
| SCHEMBL4633541 | 0.85 | CHKA (0.58) | CHKAHDAC6ALDH1A1TSHRHRH3 | |
| SCHEMBL6650843 | 0.84 | CHKA (0.61) | CHKAHDAC6ALDH1A1TSHRHRH3 | |
| SCHEMBL10174732 | 0.83 | HRH3 (0.64) | CHKAALDH1A1HRH3HPGDDRD3 | |
| SCHEMBL4367804 | 0.82 | CHKA (0.82) | CHKAHDAC6ALDH1A1HRH3HPGD | |
| SCHEMBL64588 | 0.82 | CHKA (0.82) | CHKAHDAC6ALDH1A1HRH3HPGD | |
| SCHEMBL14153328 | 0.82 | CHKA (0.58) | CHKAHDAC6ALDH1A1TSHRHRH3 | |
| SCHEMBL25509878 | 0.81 | CHKA (0.64) | CHKAHDAC6ALDH1A1TSHRHRH3 | |
| SCHEMBL10074444 | 0.81 | CHKA (0.57) | CHKAHDAC6ALDH1A1HRH3RAB9A | |
| SCHEMBL14689861 | 0.81 | NPC1 (0.61) | CHKAHDAC6ALDH1A1SLC6A2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609842-B2 | Method for synthesizing Imatinib | FUJIAN SOUTH PHARMACEUTICAL CO., LTD. (CN) | 2013-12-17 | — | — | US | disclosed |
| US-20130041149-A1 | New Method for Synthesizing Imatinib | FUJIAN SOUTH PHARMACEUTICAL CO., LTD. (CN) | 2013-02-14 | — | — | US | disclosed |
| EP-2509973-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND SALTS THEREOF | Arch Pharmalabs Limited (IN) | 2012-10-17 | — | — | EP | disclosed |
| US-20110306763-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND SALTS THEREOF | SHANGHAI PARLING PHARMATECH CO., LTD. (CN) | 2011-12-15 | — | — | US | disclosed |
| WO-2011070588-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND SALTS THEREOF | ARCH PHARMALABS LIMITED (IN) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306763-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND SALTS THEREOF | ABL1, JAK2, ABL2 | CHKA 3017/4885HDAC6 1828/4885ALDH1A1 436/4885 |
| US-20130041149-A1 | New Method for Synthesizing Imatinib | ABL1, ALK, PDGFRA | CHKA 1718/4885HDAC6 1360/4885ALDH1A1 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.