Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979691 | 1.00 | LMNA (0.51) | LMNAGAAGPBAR1ALDH1A1POLB | |
| SCHEMBL10228058 | 0.83 | LMNA (0.51) | LMNAGAAGPBAR1ALDH1A1POLB | |
| SCHEMBL601701 | 0.83 | LMNA (0.51) | LMNAGAAGPBAR1ALDH1A1POLB | |
| SCHEMBL601700 | 0.83 | LMNA (0.51) | LMNAGAAGPBAR1ALDH1A1POLB | |
| SCHEMBL603595 | 0.81 | LMNA (0.56) | LMNAGAAGPBAR1ALDH1A1POLB | |
| SCHEMBL603596 | 0.81 | LMNA (0.56) | LMNAGAAGPBAR1ALDH1A1POLB | |
| SCHEMBL10228060 | 0.81 | LMNA (0.56) | LMNAGAAGPBAR1ALDH1A1POLB | |
| SCHEMBL20502320 | 0.80 | LMNA (0.60) | LMNAGAAGPBAR1ALDH1A1POLB | |
| SCHEMBL10529805 | 0.80 | LMNA (0.60) | LMNAGAAGPBAR1ALDH1A1POLB | |
| SCHEMBL10529809 | 0.80 | LMNA (0.60) | LMNAGAAGPBAR1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509960-A1 | TGR5 AGONISTS | Exelixis, Inc. (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071565-A1 | TGR5 AGONISTS | EXELIXIS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |