Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29691070 | 1.00 | PLAU (0.52) | PLAUNOS3NOS1NOS2PDE4A | |
| SCHEMBL20162915 | 0.80 | PLAU (0.35) | PLAUPDE4ANPC1KDM4ERAB9A | |
| SCHEMBL1851255 | 0.76 | PLAU (0.61) | PLAUNOS3NOS1NOS2NPC1 | |
| SCHEMBL30785106 | 0.76 | HSD17B10 (0.41) | PLAUPDE4ANPC1KDM4ERAB9A | |
| SCHEMBL27934653 | 0.76 | KDM4E (0.33) | PLAUPDE4AKDM4EL3MBTL1MAPT | |
| SCHEMBL292776 | 0.74 | — | — | |
| SCHEMBL18397659 | 0.73 | CYP51A1 (0.31) | — | |
| SCHEMBL10971356 | 0.72 | — | — | |
| SCHEMBL6404182 | 0.72 | — | — | |
| SCHEMBL31010428 | 0.72 | PDE4A (0.33) | PLAUNOS3NOS1NOS2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105385439-B | Detect response type rhodamine fluorescence probe and its preparation and application of mercury ion | 东华大学 | 2017-12-26 | — | — | CN | claimed |
| CN-105385439-A | Reaction type Rhodamine-class fluorescence probe for mercury ion detection and preparation as well as application thereof | NAT UNIV DONG HWA | 2016-03-09 | — | — | CN | claimed |
| CN-108383888-A | One kind is for detecting biological cell Hg2+Fluorescence probe and its synthetic method | 福建师范大学泉港石化研究院 | 2018-08-10 | — | — | CN | disclosed |
| US-20180020664-A1 | SUBSTITUTED PYRIMIDINYLOXY PYRIDINE DERIVATIVES AS HERBICIDES | FMC CORPORATION | 2018-01-25 | — | — | US | disclosed |
| CN-105385439-B | Detect response type rhodamine fluorescence probe and its preparation and application of mercury ion | 东华大学 | 2017-12-26 | — | — | CN | disclosed |
| CN-103502218-B | Compounds and methods for for conjugating biomolecules | 生命科技公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-105385439-A | Reaction type Rhodamine-class fluorescence probe for mercury ion detection and preparation as well as application thereof | NAT UNIV DONG HWA | 2016-03-09 | — | — | CN | disclosed |
| CN-102105471-B | Novel compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS N.V. (BE) | 2014-10-15 | — | — | CN | disclosed |
| CN-103502218-A | Compounds and methods for conjugation of biomolecules | LIFE TECHNOLOGIES CORP | 2014-01-08 | — | — | CN | disclosed |
| CN-102105471-A | Novel compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS NV | 2011-06-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180020664-A1 | SUBSTITUTED PYRIMIDINYLOXY PYRIDINE DERIVATIVES AS HERBICIDES | DDT, CNPY2, NOX4 | PLAU 4837/4885NOS3 198/4885NOS1 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.