SCHEMBL1979849

SCHEMBL1979849

O=Cc1cccc(C=Cc2ccccn2)c1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.60
RAB9A P51151 4/20 0.60
ALDH1A1 P00352 4/20 0.60
MAPT P10636 1/20 0.60
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
ATM Q13315 1/20 0.57
PTGS1 P23219 1/20 0.50
PTGS2 P35354 1/20 0.50
IP6K1 Q92551 1/20 0.48
KDM4E B2RXH2 1/20 0.43
HPGD P15428 1/20 0.43
GRM4 Q14833 1/20 0.42
NFE2L2 Q16236 2/20 0.41
TLR4 O00206 1/20 0.40
TLR2 O60603 1/20 0.40
KDM1A O60341 1/20 0.40
CYP2A6 P11509 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1906539 1.00 NPC1 (0.60) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL30988355 1.00 NPC1 (0.60) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL1907996 0.83 MEN1 (0.64) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL1981293 0.83 MEN1 (0.64) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL30988354 0.83 MEN1 (0.64) NPC1RAB9AALDH1A1MAPTMEN1
Dipyridyl SCHEMBL28723689 0.79 KDM4E (0.59) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL9347247 0.79 KDM4E (0.56) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL6797384 0.79 CYP19A1 (0.63) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL4712207 0.79 NPC1 (0.58) NPC1RAB9AALDH1A1MAPTMEN1
SCHEMBL9131383 0.79 KDM1A (0.61) NPC1RAB9AALDH1A1MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11369559-B2 Process for treating keratin substances using a composition comprising a modified photo-dimerizable polymer L'OREAL (FR) 2022-06-28 US disclosed
US-20220087920-A1 COMPOSITION COMPRISING A MODIFIED PHOTO-DIMERIZABLE POLYMER AND AN ALKALINE AGENT AND/OR AN AMINO ALKOXYSILANE DERIVATIVE AND TREATMENT METHOD IMPLEMENTING THE COMPOSITION L'OREAL (FR) 2022-03-24 US disclosed
CN-108367167-B Method for treating keratin materials using a composition comprising a modified photodimerisable polymer 莱雅公司 2021-12-31 CN disclosed
EP-3897858-A1 COMPOSITION COMPRISING A MODIFIED PHOTO-DIMERIZABLE POLYMER AND AN ALKALINE AGENT AND/OR AN AMINO ALKOXYSILANE DERIVATIVE AND TREATMENT METHOD IMPLEMENTING THE COMPOSITION L'OREAL (FR) 2021-10-27 EP disclosed
CN-113195058-A Composition comprising a modified photodimerisable polymer and an alkaline agent and/or an aminoalkoxysilane derivative and treatment process for implementing the composition 莱雅公司 2021-07-30 CN disclosed
EP-3393592-B1 A PROCESS FOR TREATING KERATIN SUBSTANCES USING A COMPOSITION COMPRISING A MODIFIED PHOTO-DIMERIZABLE POLYMER OREAL (FR) 2021-06-09 EP disclosed
WO-2020127230-A1 COMPOSITION COMPRISING A MODIFIED PHOTO-DIMERIZABLE POLYMER AND AN ALKALINE AGENT AND/OR AN AMINO ALKOXYSILANE DERIVATIVE AND TREATMENT METHOD IMPLEMENTING THE COMPOSITION L'OREAL (FR) 2020-06-25 WO disclosed
US-20190000743-A1 A PROCESS FOR TREATING KERATIN SUBSTANCES USING A COMPOSITION COMPRISING A MODIFIED PHOTO-DIMERIZABLE POLYMER L'OREAL (FR) 2019-01-03 US disclosed
EP-3393592-A1 A PROCESS FOR TREATING KERATIN SUBSTANCES USING A COMPOSITION COMPRISING A MODIFIED PHOTO-DIMERIZABLE POLYMER L'OREAL (FR) 2018-10-31 EP disclosed
WO-2017108767-A1 A PROCESS FOR TREATING KERATIN SUBSTANCES USING A COMPOSITION COMPRISING A MODIFIED PHOTO-DIMERIZABLE POLYMER L'OREAL (FR) 2017-06-29 WO disclosed
US-5559144-A LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES ABBOTT LABORATORIES (US) 1996-09-24 US disclosed
US-5476873-A Inhibit biosynthesis of leukotrienes ABBOTT LABORATORIES (US) 1995-12-19 US disclosed
EP-0540673-A4 1994-04-27 EP disclosed
US-5234946-A Anticholesterol, antilipemic BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-08-10 US disclosed
EP-0318860-B1 SUBSTITUTED ALKYLAMINE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-06-16 EP disclosed
EP-0540673-A1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. ABBOTT LAB (US) 1993-05-12 EP disclosed
WO-1992001682-A1 ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY ABBOTT LABORATORIES (US) 1992-02-06 WO disclosed
CN-1037141-A The alkylamine derivative that replaces BANYU PHARMA CO LTD (JP) 1989-11-15 CN disclosed
EP-0318860-A2 Substituted alkylamine derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1989-06-07 EP disclosed
US-4272620-A Polyvinyl alcohol-styrylpyridinium photosensitive resins and method for manufacture thereof AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1981-06-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190000743-A1 A PROCESS FOR TREATING KERATIN SUBSTANCES USING A COMPOSITION COMPRISING A MODIFIED PHOTO-DIMERIZABLE POLYMER KRT18, KRTCAP2, CKAP4 NPC1 4815/4885RAB9A 3881/4885ALDH1A1 1833/4885
US-20220087920-A1 COMPOSITION COMPRISING A MODIFIED PHOTO-DIMERIZABLE POLYMER AND AN ALKALINE AGENT AND/OR AN AMINO ALKOXYSILANE DERIVATIVE AND TREATMENT METHOD IMPLEMENTING THE COMPOSITION ACP1, ALAD, PHOSPHO1 NPC1 4834/4885RAB9A 3342/4885ALDH1A1 2122/4885
US-11369559-B2 Process for treating keratin substances using a composition comprising a modified photo-dimerizable polymer KRT18, KRTCAP2, CKAP4 NPC1 4803/4885RAB9A 3564/4885ALDH1A1 2099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.