Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19798890 | 1.00 | ACHE (0.36) | ACHEKDM2BSCN1ASCN4ASCN7A | |
| SCHEMBL19798879 | 1.00 | ACHE (0.36) | ACHEKDM2BSCN1ASCN4ASCN7A | |
| SCHEMBL19798888 | 1.00 | ACHE (0.36) | ACHEKDM2BSCN1ASCN4ASCN7A | |
| SCHEMBL24843742 | 0.84 | SCN1A (0.42) | ACHESCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL19799016 | 0.82 | ACHE (0.45) | ACHEKDM2BSCN1ASCN4ASCN7A | |
| SCHEMBL19799009 | 0.82 | ACHE (0.45) | ACHEKDM2BSCN1ASCN4ASCN7A | |
| SCHEMBL21120575 | 0.82 | ACHE (0.45) | ACHEKDM2BSCN1ASCN4ASCN7A | |
| SCHEMBL19799007 | 0.82 | ACHE (0.45) | ACHEKDM2BSCN1ASCN4ASCN7A | |
| SCHEMBL19798944 | 0.80 | KDM2B (0.37) | KDM2BSCN1ASCN4ASCN7AKCNH2 | |
| SCHEMBL19798936 | 0.80 | KDM2B (0.37) | KDM2BSCN1ASCN4ASCN7AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180022727-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022727-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | KDM1B, KDM6B, KDM2B | ACHE 2492/4885KDM2B 3/4885SCN1A 2558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.