Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 9/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350253 | 0.94 | PKM (0.49) | PKMHDAC1HDAC6 | |
| SCHEMBL3358237 | 0.92 | PKM (0.47) | PKMHDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL196506 | 0.89 | HDAC1 (0.53) | PKMHDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL3353423 | 0.85 | PKM (0.47) | PKMHDAC1HDAC3HDAC6HDAC7 | |
| SCHEMBL197923 | 0.84 | HDAC1 (0.39) | HDAC1HDAC3HDAC2HDAC6HDAC7 | |
| SCHEMBL197443 | 0.83 | CDK2 (0.44) | HDAC1HDAC3HDAC2HDAC6HDAC7 | |
| SCHEMBL198039 | 0.83 | KCNH2 (0.35) | HDAC1HDAC3HDAC2HDAC6HDAC7 | |
| SCHEMBL199233 | 0.83 | HDAC1 (0.39) | HDAC1HDAC3HDAC2HDAC6HDAC7 | |
| SCHEMBL198526 | 0.82 | HDAC6 (0.39) | HDAC1HDAC3HDAC2HDAC6HDAC7 | |
| SCHEMBL3351902 | 0.82 | HDAC1 (0.56) | PKMHDAC1HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088771-B2 | Cycloalkylidene and heterocycloalkylidene inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-20100022543-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-01-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022543-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC2 | PKM 1086/4885HDAC1 1/4885HDAC3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.