Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK2 | Q9NYY3 | 6/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | NEK5 | Q6P3R8 | 1/20 | 0.37 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1981355 | 0.90 | PLK2 (0.52) | PLK2RIPK2ACVR1FGFR1SRC | |
| SCHEMBL13385778 | 0.90 | PLK2 (0.44) | PLK2RIPK2FGFR1SRCABL1 | |
| SCHEMBL13385833 | 0.89 | PLK2 (0.44) | PLK2RIPK2ACVR1FGFR1NEK2 | |
| SCHEMBL1983011 | 0.87 | PLK2 (0.56) | PLK2RIPK2FGFR1SRCNEK2 | |
| SCHEMBL1980519 | 0.82 | PLK2 (0.43) | PLK2RIPK2ACVR1FGFR1SRC | |
| SCHEMBL1985316 | 0.81 | PLK2 (0.55) | PLK2RIPK2ACVR1FGFR1SRC | |
| SCHEMBL1981941 | 0.81 | PLK2 (0.56) | PLK2MAPK14NEK2NEK5NEK1 | |
| SCHEMBL13385888 | 0.77 | ALDH1A1 (0.43) | PLK2FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL1982506 | 0.76 | ALDH1A1 (0.42) | PLK2FGFR1SRCEGFRFGFR2 | |
| SCHEMBL1982820 | 0.74 | ALDH1A1 (0.39) | PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889696-B2 | Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120269831-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-10-25 | — | — | US | disclosed |
| EP-2512250-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | Temple University - Of The Commonwealth System of Higher Education (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075616-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120269831-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | MKI67, CCNA1, FOLR1 | PLK2 224/4885RIPK2 4392/4885ACVR1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.