SCHEMBL198050

SCHEMBL198050

COC(CCCC(N)C(=O)O)OC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSR P00390 2/20 0.52
DDAH1 O94760 3/20 0.50
NOS2 P35228 7/20 0.47
NOS1 P29475 6/20 0.47
NOS3 P29474 4/20 0.47
CYP2C19 P33261 2/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
ARG2 P78540 4/20 0.47
ARG1 P05089 3/20 0.47
CYP1A2 P05177 3/20 0.46
TSHR P16473 2/20 0.46
CYP3A4 P08684 1/20 0.46
GLA P06280 1/20 0.46
NFKB1 P19838 1/20 0.46
APEX1 P27695 1/20 0.46
GRM8 O00222 1/20 0.45
GRM6 O15303 1/20 0.45
GRIN2D O15399 1/20 0.45
GRIN3B O60391 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2683497 1.00 GSR (0.52) GSRDDAH1NOS2NOS1NOS3
SCHEMBL2683210 1.00 GSR (0.52) GSRDDAH1NOS2NOS1NOS3
SCHEMBL198870 0.88 DDAH1 (0.42) GSRDDAH1NOS2NOS1NOS3
SCHEMBL3188542 0.87 GSR (0.48) GSRDDAH1NOS2NOS1NOS3
SCHEMBL6889595 0.87 GSR (0.48) GSRDDAH1NOS2NOS1NOS3
SCHEMBL28970370 0.87 GSR (0.48) GSRDDAH1NOS2NOS1NOS3
SCHEMBL7023567 0.83 DDAH1 (0.39) GSRDDAH1NOS2NOS1NOS3
SCHEMBL18834060 0.82 GSR (0.47) GSRDDAH1NOS2NOS1NOS3
SCHEMBL29289 0.82 GSR (0.71) GSRNOS2NOS1NOS3CYP2C19
SCHEMBL10135848 0.82 GSR (0.71) GSRNOS2NOS1NOS3CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1235792-A4 PREPARATION OF [4S-(4ALPHA,7ALPHA,10ABETA)]-4-AMINO-OCTAHYDRO-5-OXO-7H-PYRIDO 2,1-B] 1,3]THIAZEPINE-7-CARBOXYLIC ACID, METHYL ESTER AND SALTS THEREOF VIA NOVEL DISULFIDES BRISTOL MYERS SQUIBB CO (US) 2003-06-25 EP claimed
EP-1121351-A4 PREPARATION OF (S)-2-AMINO-6,6-DIMETHOXYHEXANOIC ACID METHYL ESTER VIA NOVEL DIOXOLANES BRISTOL MYERS SQUIBB CO (US) 2003-05-02 EP claimed
EP-1235792-A1 PREPARATION OF [4S-(4ALPHA,7ALPHA,10ABETA)]-4-AMINO-OCTAHYDRO-5-OXO-7H-PYRIDO 2,1-B] 1,3]THIAZEPINE-7-CARBOXYLIC ACID, METHYL ESTER AND SALTS THEREOF VIA NOVEL DISULFIDES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-09-04 EP claimed
WO-2002042258-A1 PREPARATION OF [4S-(4α,7α,10Aβ)]-4-AMINO-OCTAHYDRO-5-OXO-7H-PYRIDO[2,1-B][1,3]THIAZEPINE-7-CARBOXYLIC ACID, METHYL ESTER AND SALTS THEREOF VIA NOVEL DISULFIDES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-05-30 WO claimed
US-6329542-B1 GLYCINAMIDE DERIVATIVE IS REACTED WITH DIOXOLANE COMPOUND, TREATING INTERMEDIATE WITH WATER AND REFLUXING TO GIVE DIOXOLANE PENTANOIC ACID COMPOUND WHICH IS TREATED TO EXCHANGE THE DIOXOLANE ACETAL WITH A DIMETHOXY ACETAL, ESTERIFICATION BRISTOL-MYERS SQUIBB CO. 2001-12-11 US claimed
EP-1121351-A2 PREPARATION OF (S)-2-AMINO-6,6-DIMETHOXYHEXANOIC ACID METHYL ESTER VIA NOVEL DIOXOLANES BRISTOL-MYERS SQUIBB COMPANY (US) 2001-08-08 EP claimed
US-6248882-B1 VIA DIOXOLANE INTERMEDIATES BRISTOL-MYERS SQUIBB CO. 2001-06-19 US claimed
US-6162913-A Preparation of [4S-(4α,7α,10aβ)]-4-amino-octahydro-5-oxo-7H-pyrido[2,1 -b] [1,3]thiazepine-7-carboxylic acid, methyl ester and salts thereof via novel disulfides BRISTOL-MYERS SQUIBB CO. (US) 2000-12-19 US claimed
WO-2000003981-A2 PREPARATION OF (S)-2-AMINO-6,6-DIMETHOXYHEXANOIC ACID METHYL ESTER VIA NOVEL DIOXOLANES BRISTOL-MYERS SQUIBB COMPANY (US) 2000-01-27 WO claimed
US-5627278-A MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION BRISTOL-MYERS SQUIBB CO. (US) 1997-05-06 US claimed
US-9828594-B2 Nitrilases, nucleic acids encoding them and methods for making and using them BASF ENZYMES LLC (US) 2017-11-28 US disclosed
US-9828594-B2 Nitrilases, nucleic acids encoding them and methods for making and using them BASF ENZYMES LLC (US) 2017-11-28 US disclosed
US-20160355801-A1 NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM VERENIUM CORPORATION 2016-12-08 US disclosed
US-9315792-B2 Nitrilases, nucleic acids encoding them and methods for making and using them BASF ENZYMES LLC (US) 2016-04-19 US disclosed
US-9217164-B2 Nitrilases, nucleic acids encoding them and methods for making and using them BASF ENZYMES LLC (US) 2015-12-22 US disclosed
US-5670699-A Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring BRISTOL-MYERS SQUIBB CO. (US) 1997-09-23 US disclosed
US-5627278-A MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION BRISTOL-MYERS SQUIBB CO. (US) 1997-05-06 US disclosed
US-5616775-A ESTERIFYING A N-PROTECTED METHIONINE; OXIDIZING; REACTING WITH AN ACID ANHYDRIDE THEN AN ALKALI METAL HYDROXIDE BRISTOL-MYERS SQUIBB CO. (US) 1997-04-01 US disclosed
US-5508272-A SELECTIVE ACE INHIBITORS, HYPOTENSIVE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1996-04-16 US disclosed
EP-0629627-A2 Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 1994-12-21 EP disclosed