Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 13/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912217 | 0.91 | SDHB (0.69) | SDHBMAPTTP53POLB | |
| SCHEMBL19805828 | 0.90 | SDHB (0.70) | SDHBMAPTTP53POLB | |
| SCHEMBL19805969 | 0.90 | SDHB (0.70) | SDHBMAPTTP53POLBKDM4E | |
| SCHEMBL22912222 | 0.89 | SDHB (0.71) | SDHBMAPTTP53POLB | |
| SCHEMBL19805739 | 0.89 | SDHB (0.64) | SDHBMAPTTP53POLBKDM4E | |
| SCHEMBL22912195 | 0.89 | SDHB (0.63) | SDHBMAPTTP53POLBKDM4E | |
| SCHEMBL19805906 | 0.88 | SDHB (0.71) | SDHBMAPTTP53POLBKDM4E | |
| SCHEMBL19805824 | 0.86 | SDHB (0.73) | SDHBMAPTTP53POLBKDM4E | |
| SCHEMBL30526113 | 0.85 | SDHB (0.69) | SDHBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL19806068 | 0.85 | SDHB (0.69) | SDHBMAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |