Sugi Predict

Sugi Predict / Targets / SDHB

SDHB

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial · P21912 · SDHB on Sugi Atlas →

3,457 patent compounds predicted against SDHB, 1,539 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL3569045 SCHEMBL3569045 0.76 13/20
SCHEMBL8265074 SCHEMBL8265074 0.57 13/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL5182960) 0.56 13/20
SCHEMBL1829027 SCHEMBL1829027 0.54 11/20
SCHEMBL8446796 SCHEMBL8446796 0.54 11/20
SCHEMBL1830578 SCHEMBL1830578 0.65 10/20
SCHEMBL76774 SCHEMBL76774 0.60 10/20
SCHEMBL8560362 SCHEMBL8560362 0.56 10/20
SCHEMBL5375362 SCHEMBL5375362 0.60 9/20
SCHEMBL5593337 SCHEMBL5593337 0.72 8/20
SCHEMBL5444851 SCHEMBL5444851 0.52 8/20
SCHEMBL3875432 SCHEMBL3875432 0.51 8/20
SCHEMBL1183883 SCHEMBL1183883 0.50 8/20
SCHEMBL9903777 SCHEMBL9903777 0.35 8/20
SCHEMBL13912201 SCHEMBL13912201 0.66 7/20
SCHEMBL7871659 SCHEMBL7871659 0.62 7/20
SCHEMBL13912177 SCHEMBL13912177 0.59 7/20
SCHEMBL8665226 SCHEMBL8665226 0.58 7/20
SCHEMBL5748949 SCHEMBL5748949 0.41 7/20
SCHEMBL8467175 SCHEMBL8467175 0.41 7/20

Clinical trials — most relevant to SDHB by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phenoxybenzamine Versus Doxazosin in PCC Patients PHASE4COMPLETED
Coenzyme Q10 in Older Athletes Treated With Statin Medications PHASE4COMPLETED
A Study of Olverembatinib in SDH-deficient GIST. PHASE3RECRUITING
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST PHASE2COMPLETED
The Efficacy and Safety of Temozolomide in SDH-deficient GIST PHASE2RECRUITING
Temozolomide (TMZ) in Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST) PHASE2ACTIVE_NOT_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting. PHASE2ACTIVE_NOT_RECRUITING
A Study of HQP1351 in Patients With GIST or Other Solid Tumors PHASE1RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study nanNOT_YET_RECRUITING
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers nanNOT_YET_RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer) nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
Study Investigating MEN1 and SDHD in Familial Carcinoid Tumors nanUNKNOWN
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
The Natural History of Mitochondrial Diseases nanRECRUITING
Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors nanRECRUITING
Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals nanRECRUITING
The International Registry for Leigh Syndrome nanRECRUITING
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED
Effect of Diaphragm Stimulation During Surgery nanCOMPLETED
BMPR2 Mutations and Iron Metabolism in Pulmonary Arterial Hypertension nanCOMPLETED
Rhizomelic Chondrodysplasia Punctata Registry nanRECRUITING
Natural History Study of Pyruvate Dehydrogenase Deficiency nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a SDHB binder may also engage these)

ProteinNameSimilarity
Q007T0 — 1.000 Q007T0 →
Q9CQA3 — 0.999 Q9CQA3 →
Q3T189 — 0.998 Q3T189 →
B0BM36 — 0.998 B0BM36 →
P21914 — 0.998 P21914 →
Q3B8J8 — 0.997 Q3B8J8 →
Q9YHT2 — 0.997 Q9YHT2 →
O42772 — 0.997 O42772 →
Q6FWS8 — 0.997 Q6FWS8 →
A5PL98 — 0.996 A5PL98 →
P21913 — 0.995 P21913 →
Q8LBZ7 — 0.994 Q8LBZ7 →
P32420 — 0.994 P32420 →
P21801 — 0.994 P21801 →
Q9FJP9 — 0.993 Q9FJP9 →
Q8LB02 — 0.993 Q8LB02 →
Q55CC2 — 0.992 Q55CC2 →
Q75CI4 — 0.991 Q75CI4 →
O44074 — 0.991 O44074 →
Q70KF8 — 0.990 Q70KF8 →
Q09545 — 0.990 Q09545 →
P21911 — 0.989 P21911 →
A8WPF0 — 0.988 A8WPF0 →
Q68XS0 — 0.987 Q68XS0 →
Q59662 — 0.987 Q59662 →
Q9S827 — 0.986 Q9S827 →
Q92JJ8 — 0.985 Q92JJ8 →
Q6H4G3 — 0.983 Q6H4G3 →
P20921 — 0.982 P20921 →
Q1RGP3 — 0.982 Q1RGP3 →