Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2950197 | 0.96 | RET (0.46) | RETKCNK3KCNK9AR | |
| SCHEMBL2943421 | 0.90 | AR (0.43) | AR | |
| SCHEMBL2950177 | 0.88 | PPARA (0.50) | AR | |
| SCHEMBL2942158 | 0.87 | AR (0.43) | AR | |
| SCHEMBL21531757 | 0.84 | AR (0.44) | AR | |
| SCHEMBL18804890 | 0.84 | AR (0.46) | AR | |
| SCHEMBL12579986 | 0.84 | AR (0.45) | AR | |
| SCHEMBL23607575 | 0.83 | KCNK3 (0.48) | KCNK3KCNK9 | |
| SCHEMBL29711728 | 0.83 | TRPV1 (0.48) | RETKCNK3KCNK9 | |
| SCHEMBL998270 | 0.83 | TRPV1 (0.48) | RETKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317074-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2021-10-14 | — | — | US | disclosed |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-05-19 | — | — | US | disclosed |
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | RET 2036/4885KCNK3 3762/4885KCNK9 3266/4885 |
| US-20210317074-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | EP300, KAT2A, NAA40 | RET 2652/4885KCNK3 4074/4885KCNK9 3736/4885 |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | HDAC6, HDAC9, HDAC5 | RET 2036/4885KCNK3 3762/4885KCNK9 3266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.