Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.77 |
| ▸ | JAK2 | O60674 | 7/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24062654 | 0.90 | JAK1 (0.80) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL19823050 | 0.87 | JAK1 (1.00) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL19823061 | 0.86 | JAK1 (0.75) | JAK1JAK2JAK3 | |
| SCHEMBL21044824 | 0.86 | JAK1 (1.00) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL19823062 | 0.85 | JAK1 (0.75) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL13535559 | 0.85 | JAK1 (0.73) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL21044823 | 0.85 | JAK1 (0.84) | JAK1JAK2JAK3PTK2 | |
| SCHEMBL24062649 | 0.84 | JAK1 (0.72) | JAK1JAK2JAK3 | |
| SCHEMBL13535409 | 0.82 | JAK1 (0.70) | JAK1JAK2 | |
| SCHEMBL13535386 | 0.81 | JAK1 (0.72) | JAK1JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018019223-A1 | COMPOUND AS SELECTIVE JAK INHIBITOR, AND SALT AND THERAPEUTIC USE THEREOF | 张文燕 | 2018-02-01 | — | — | WO | disclosed |