Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 4/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24042179 | 0.80 | CHRNB2 (0.43) | CHRNB2CHRNA4HTR1BHTR1DTAAR1 | |
| SCHEMBL14422893 | 0.77 | HTR1B (0.52) | CHRNB2CHRNA4HTR1BHTR1DKDM4E | |
| SCHEMBL18994375 | 0.77 | NPC1 (0.46) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL13827717 | 0.75 | NPC1 (0.58) | KDM4EALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL13819972 | 0.72 | IDO1 (0.36) | SMN1; SMN2NPC1RAB9AHSD17B10RXRA | |
| SCHEMBL24348387 | 0.72 | POLB (0.43) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL22536868 | 0.70 | HTR1B (0.52) | CHRNB2CHRNA4HTR1BHTR1DKDM4E | |
| SCHEMBL2472084 | 0.69 | HTR1B (0.64) | CHRNB2CHRNA4HTR1BHTR1DKDM4E | |
| SCHEMBL10922023 | 0.69 | MAPT (0.55) | CHRNB2CHRNA4HTR1BHTR1DKDM4E | |
| Hydrochloric Acid SCHEMBL21595631 | 0.68 | HTR1B (0.62) | CHRNB2CHRNA4HTR1BHTR1DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3275870-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | Gilead Sciences, Inc. (US) | 2018-01-31 | — | — | EP | disclosed |