Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19815831 | 0.82 | TP53 (0.45) | LRRK2TP53KDM4EMAPTALDH1A1 | |
| SCHEMBL19815575 | 0.81 | TP53 (0.47) | LRRK2TP53KDM4EMAPTALDH1A1 | |
| SCHEMBL20862642 | 0.70 | JAK3 (0.55) | LRRK2JAK3TP53KDM4EMAPT | |
| SCHEMBL20862666 | 0.70 | JAK3 (0.55) | LRRK2JAK3TP53KDM4EMAPT | |
| SCHEMBL18967907 | 0.70 | LRRK2 (1.00) | LRRK2JAK3JAK2JAK1 | |
| SCHEMBL15402055 | 0.70 | LRRK2 (1.00) | LRRK2JAK3JAK2JAK1 | |
| SCHEMBL15402331 | 0.69 | LRRK2 (0.47) | LRRK2JAK3TP53KDM4EMAPT | |
| SCHEMBL15401762 | 0.69 | LRRK2 (0.47) | LRRK2JAK3TP53KDM4EMAPT | |
| SCHEMBL19725048 | 0.68 | JAK3 (0.51) | LRRK2JAK3TP53MAPTLMNA | |
| SCHEMBL19826713 | 0.68 | TP53 (0.44) | LRRK2TP53KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018021977-A1 | GLYCINE METABOLISM MODULATORS AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-02-01 | — | — | WO | disclosed |