Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | GAA | P10253 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.75 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12765863 | 1.00 | KDM4E (0.98) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2216260 | 1.00 | KDM4E (0.98) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11366297 | 0.91 | KDM4E (0.82) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1491317 | 0.86 | KDM4E (1.00) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL19161142 | 0.86 | KDM4E (1.00) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1491505 | 0.86 | KDM4E (1.00) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1491315 | 0.86 | KDM4E (1.00) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20524879 | 0.85 | KDM4E (0.73) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL29535576 | 0.85 | KDM4E (0.73) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11881740 | 0.85 | KDM4E (0.73) | KDM4EHSD17B10CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295673-A1 | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-09-21 | — | — | US | disclosed |
| US-10947572-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | CODEXIS, INC. (US) | 2021-03-16 | — | — | US | disclosed |
| EP-3068793-B1 | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | CODEXIS INC (US) | 2021-02-17 | — | — | EP | disclosed |
| US-10787689-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | CODEXIS, INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20200032303-A1 | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2020-01-30 | — | — | US | disclosed |
| US-10407668-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | CODEXIS, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-20180030419-A1 | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2018-02-01 | — | — | US | disclosed |