SCHEMBL20524879

SCHEMBL20524879

O=C(OCc1ccccc1)C1Cc2c([nH]c3ccccc23)CN1

nearest known ligand 0.98

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.73
CYP1A2 P05177 2/20 0.73
CYP2D6 P10635 2/20 0.73
CYP2C9 P11712 2/20 0.73
CYP2C19 P33261 2/20 0.73
HSD17B10 Q99714 2/20 0.73
MAPK1 P28482 1/20 0.73
ALDH1A1 P00352 2/20 0.68
GAA P10253 1/20 0.68
MAPT P10636 1/20 0.68
HPGD P15428 1/20 0.68
ALOX15 P16050 1/20 0.68
TRPM8 Q7Z2W7 1/20 0.55
TACR1 P25103 1/20 0.46
CYP19A1 P11511 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29535576 1.00 KDM4E (0.73) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL5880414 1.00 KDM4E (0.73) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL2216260 0.85 KDM4E (0.98) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL12765863 0.85 KDM4E (0.98) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL19829391 0.85 KDM4E (0.98) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL11881740 0.83 KDM4E (0.73) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL19161142 0.81 KDM4E (1.00) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL1491317 0.81 KDM4E (1.00) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL1491505 0.81 KDM4E (1.00) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL1491315 0.81 KDM4E (1.00) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630512-B2 Agents for differentiating stem cells and treating cancer MINERVA BIOTECHNOLOGIES CORPORATION (US) 2026-05-19 US disclosed
EP-3600451-B1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORP (US) 2025-12-24 EP disclosed
US-12202799-B2 Agents for differentiating stem cells and treating cancer MINERVA BIOTECHNOLOGIES CORPORATION (US) 2025-01-21 US disclosed
US-20240409515-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORPORATION 2024-12-12 US disclosed
US-20220242823-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORPORATION 2022-08-04 US disclosed
US-20210299109-A1 AGENTS FOR TREATING CANCER AND METHODS FOR IDENTIFYING SAID AGENTS MINERVA BIOTECHNOLOGIES CORPORATION 2021-09-30 US disclosed
US-20210087143-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORP (US) 2021-03-25 US disclosed
EP-3600451-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER Minerva Biotechnologies Corporation (US) 2020-02-05 EP disclosed
WO-2018183654-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORPORATION (US) 2018-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210299109-A1 AGENTS FOR TREATING CANCER AND METHODS FOR IDENTIFYING SAID AGENTS MCL1, CD44, EPCAM KDM4E 970/4885CYP1A2 4081/4885CYP2D6 4379/4885
US-12202799-B2 Agents for differentiating stem cells and treating cancer MCL1, CD44, CRABP2 KDM4E 2543/4885CYP1A2 4669/4885CYP2D6 4801/4885
US-20210087143-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MCL1, CD44, CRABP2 KDM4E 2543/4885CYP1A2 4669/4885CYP2D6 4801/4885
US-12630512-B2 Agents for differentiating stem cells and treating cancer MCL1, POU2F1, NES KDM4E 1753/4885CYP1A2 2832/4885CYP2D6 3225/4885
US-20240409515-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MCL1, CD44, CRABP2 KDM4E 2543/4885CYP1A2 4669/4885CYP2D6 4801/4885
US-20220242823-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MCL1, CD44, CRABP2 KDM4E 2543/4885CYP1A2 4669/4885CYP2D6 4801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.