Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.69 |
| ▸ | JAK1 | P23458 | 11/20 | 0.69 |
| ▸ | JAK3 | P52333 | 5/20 | 0.69 |
| ▸ | TYK2 | P29597 | 2/20 | 0.69 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.54 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99794 | 0.92 | JAK2 (0.71) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL14331887 | 0.88 | JAK2 (0.71) | JAK2JAK1JAK3TYK2AURKA | |
| SCHEMBL19831998 | 0.87 | JAK2 (0.75) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL24261752 | 0.87 | JAK2 (0.66) | JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL4086730 | 0.83 | JAK1 (0.66) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL22421430 | 0.82 | JAK2 (0.70) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18975893 | 0.82 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL29389911 | 0.82 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL24860470 | 0.82 | JAK2 (0.74) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18975895 | 0.82 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492468-B1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | SUZHOU LONGBIOTECH PHARMACEUTICALS CO LTD (CN) | 2022-02-23 | — | — | EP | disclosed |
| EP-3492468-A1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | Tianjin Longbogene Pharmaceutical Co., Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |
| WO-2018019222-A1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | 张文燕 | 2018-02-01 | — | — | WO | disclosed |