Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.66 |
| ▸ | JAK1 | P23458 | 11/20 | 0.66 |
| ▸ | JAK3 | P52333 | 5/20 | 0.66 |
| ▸ | TYK2 | P29597 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99794 | 0.89 | JAK2 (0.71) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19831999 | 0.87 | JAK2 (0.69) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19832215 | 0.86 | JAK2 (0.74) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL14331887 | 0.85 | JAK2 (0.71) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19832252 | 0.85 | JAK2 (0.73) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19831998 | 0.85 | JAK2 (0.75) | JAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL4086730 | 0.81 | JAK1 (0.66) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL22421430 | 0.80 | JAK2 (0.70) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL18975893 | 0.79 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL29389911 | 0.79 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492468-B1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | SUZHOU LONGBIOTECH PHARMACEUTICALS CO LTD (CN) | 2022-02-23 | — | — | EP | disclosed |