Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.83 |
| ▸ | JAK3 | P52333 | 6/20 | 0.83 |
| ▸ | JAK2 | O60674 | 8/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19832265 | 0.91 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL19832021 | 0.88 | JAK1 (1.00) | JAK1JAK3JAK2 | |
| SCHEMBL21084573 | 0.88 | JAK1 (0.83) | JAK1JAK3JAK2 | |
| SCHEMBL21085370 | 0.86 | JAK1 (0.81) | JAK1JAK3JAK2 | |
| SCHEMBL19832171 | 0.86 | JAK1 (0.60) | JAK1JAK3JAK2 | |
| SCHEMBL19832232 | 0.85 | JAK1 (0.79) | JAK1JAK3JAK2 | |
| SCHEMBL19832103 | 0.83 | JAK1 (0.77) | JAK1JAK3JAK2 | |
| SCHEMBL19832102 | 0.83 | JAK1 (0.73) | JAK1JAK3JAK2 | |
| SCHEMBL19832215 | 0.79 | JAK2 (0.74) | JAK1JAK3JAK2 | |
| SCHEMBL19832074 | 0.78 | JAK1 (1.00) | JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492468-A1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | Tianjin Longbogene Pharmaceutical Co., Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |
| WO-2018019222-A1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | 张文燕 | 2018-02-01 | — | — | WO | disclosed |