Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.74 |
| ▸ | JAK1 | P23458 | 15/20 | 0.51 |
| ▸ | JAK3 | P52333 | 6/20 | 0.51 |
| ▸ | TYK2 | P29597 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24261752 | 0.86 | JAK2 (0.66) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19832220 | 0.85 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19831989 | 0.83 | JAK2 (0.75) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19832171 | 0.83 | JAK1 (0.60) | JAK2JAK1JAK3 | |
| SCHEMBL19831987 | 0.82 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL21320195 | 0.80 | JAK2 (0.72) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL21044799 | 0.80 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL24261767 | 0.79 | JAK2 (0.73) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19832020 | 0.79 | JAK1 (0.83) | JAK2JAK1JAK3 | |
| SCHEMBL19832001 | 0.78 | JAK2 (0.71) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492468-B1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | SUZHOU LONGBIOTECH PHARMACEUTICALS CO LTD (CN) | 2022-02-23 | — | — | EP | disclosed |
| EP-3492468-A1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | Tianjin Longbogene Pharmaceutical Co., Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |
| WO-2018019222-A1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | 张文燕 | 2018-02-01 | — | — | WO | disclosed |