Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.59 |
| ▸ | JAK1 | P23458 | 7/20 | 0.52 |
| ▸ | JAK3 | P52333 | 4/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | PRKACA | P17612 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19831989 | 0.89 | JAK2 (0.75) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL21085370 | 0.82 | JAK1 (0.81) | JAK2JAK1JAK3 | |
| SCHEMBL19832076 | 0.75 | JAK2 (0.56) | JAK2JAK1JAK3TYK2PRKCQ | |
| SCHEMBL19832266 | 0.75 | JAK1 (0.64) | JAK2JAK1JAK3TYK2CDC7 | |
| SCHEMBL19831987 | 0.74 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL19832001 | 0.73 | JAK2 (0.71) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL29869934 | 0.73 | AURKA (0.64) | JAK2PDPK1TGFBR1IKBKETBK1 | |
| SCHEMBL24261745 | 0.72 | JAK1 (0.63) | JAK2JAK1JAK3CDC7CDK2 | |
| SCHEMBL19832075 | 0.72 | JAK2 (0.75) | JAK2JAK1JAK3TYK2ROCK2 | |
| SCHEMBL21044799 | 0.72 | JAK2 (1.00) | JAK2JAK1JAK3TYK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018019222-A1 | HETEROCYCLIC COMPOUND AS JAK INHIBITOR, AND SALTS AND THERAPEUTIC USE THEREOF | 张文燕 | 2018-02-01 | — | — | WO | disclosed |