Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.64 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.64 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.64 |
| ▸ | MET | P08581 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.55 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.54 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30399814 | 0.85 | AURKA (0.49) | AURKAAURKBINCENPTPX2MET | |
| SCHEMBL26174515 | 0.85 | AURKA (0.49) | AURKAAURKBINCENPTPX2MET | |
| SCHEMBL12501033 | 0.79 | AURKA (0.50) | AURKAAURKBINCENPTPX2MET | |
| SCHEMBL2753672 | 0.79 | ALK (0.74) | PDPK1ALK | |
| SCHEMBL1718255 | 0.78 | AURKB (1.00) | AURKAAURKBINCENPTPX2ROCK2 | |
| SCHEMBL18789185 | 0.78 | LRRK2 (0.56) | AURKAAURKBINCENPTPX2ROCK2 | |
| SCHEMBL16703358 | 0.78 | GRM4 (0.65) | AURKAAURKBINCENPTPX2MET | |
| SCHEMBL13505042 | 0.76 | MAPK8 (0.59) | AURKAAURKBINCENPTPX2PDPK1 | |
| SCHEMBL3350111 | 0.76 | ALK (0.59) | AURKAAURKBINCENPTPX2PDPK1 | |
| SCHEMBL29870401 | 0.76 | CDC7 (0.60) | PDPK1TGFBR1IKBKETBK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | PDXK, CCNK, CDC42BPB | AURKA 316/4885AURKB 81/4885INCENP 2844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.