Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 5/20 | 0.34 |
| ▸ | DRD5 | P21918 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | DRD4 | P21917 | 4/20 | 0.33 |
| ▸ | DRD3 | P35462 | 4/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | INMT | O95050 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24815574 | 0.85 | — | — | |
| SCHEMBL13557885 | 0.84 | DRD1 (0.33) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL24815589 | 0.73 | — | — | |
| SCHEMBL16984238 | 0.73 | DPP7 (0.38) | DRD1DRD5 | |
| SCHEMBL16229278 | 0.71 | CHRNA7 (0.36) | — | |
| SCHEMBL19684425 | 0.70 | L3MBTL3 (0.31) | — | |
| SCHEMBL13006727 | 0.69 | SETD7 (0.46) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL24815588 | 0.68 | DPP7 (0.41) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL3745474 | 0.67 | — | — | |
| SCHEMBL295342 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492462-A1 | AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY | Shenzhen Targetrx, Inc. (CN) | 2019-06-05 | — | — | EP | disclosed |
| WO-2018019204-A1 | AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY | 深圳市塔吉瑞生物医药有限公司 | 2018-02-01 | — | — | WO | disclosed |