Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 20/20 | 1.00 |
| ▸ | TLR7 | Q9NYK1 | 17/20 | 1.00 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.90 |
| ▸ | TLR4 | O00206 | 2/20 | 0.90 |
| ▸ | TLR3 | O15455 | 2/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29555446 | 1.00 | TLR9 (1.00) | TLR9TLR7TLR8TLR4TLR3 | |
| SCHEMBL19839195 | 0.94 | TLR9 (1.00) | TLR9TLR7TLR8TLR4TLR3 | |
| Hydrochloric Acid SCHEMBL19838783 | 0.94 | TLR9 (0.98) | TLR9TLR7TLR8TLR4TLR3 | |
| Hydrochloric Acid SCHEMBL29555536 | 0.94 | TLR9 (0.98) | TLR9TLR7TLR8TLR4TLR3 | |
| SCHEMBL29555563 | 0.90 | TLR9 (0.82) | TLR9TLR7TLR8TLR4TLR3 | |
| SCHEMBL19838706 | 0.90 | TLR9 (0.82) | TLR9TLR7TLR8TLR4TLR3 | |
| SCHEMBL19838366 | 0.88 | TLR9 (0.81) | TLR9TLR7TLR8TLR4TLR3 | |
| SCHEMBL29555646 | 0.88 | TLR9 (0.81) | TLR9TLR7TLR8TLR4TLR3 | |
| SCHEMBL19850067 | 0.87 | TLR7 (0.79) | TLR9TLR7TLR8TLR4TLR3 | |
| SCHEMBL19838376 | 0.86 | TLR9 (0.78) | TLR9TLR7TLR8TLR4TLR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180474-B2 | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-11-23 | — | — | US | claimed |
| US-20210292300-A1 | DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-23 | — | — | US | claimed |
| EP-3490983-A1 | DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-06-05 | — | — | EP | claimed |
| WO-2018026620-A1 | DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-08 | — | — | WO | claimed |
| US-20240016813-A1 | METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION | Accencio LLC | 2024-01-18 | — | — | US | disclosed |
| CN-109715617-B | Dimethoxyphenyl-substituted indole compounds as inhibitors of TLR7, TLR8 or TLR9 | 百时美施贵宝公司 | 2022-04-19 | — | — | CN | disclosed |
| US-11180474-B2 | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-11-23 | — | — | US | disclosed |
| US-20210292300-A1 | DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-23 | — | — | US | disclosed |
| EP-3490983-A1 | DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-06-05 | — | — | EP | disclosed |
| WO-2018026620-A1 | DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210292300-A1 | DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS | TLR9, TLR7, TLR8 | TLR9 1/4885TLR7 2/4885TLR8 3/4885 |
| US-20240016813-A1 | METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION | ACE2, ACE, TMPRSS2 | TLR9 1190/4885TLR7 1436/4885TLR8 878/4885 |
| US-11180474-B2 | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors | TLR9, TLR7, TLR8 | TLR9 1/4885TLR7 2/4885TLR8 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.