Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 8/20 | 0.35 |
| ▸ | RAB9A | P51151 | 8/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19841033 | 0.90 | NPC1 (0.39) | MEN1KMT2AMAPTPOLBTDP1 | |
| SCHEMBL19840702 | 0.89 | EPHX2 (0.43) | EPHX2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL19841133 | 0.85 | HDAC3 (0.31) | — | |
| SCHEMBL19840707 | 0.83 | MAPT (0.39) | EPHX2MEN1KMT2AMAPTPOLB | |
| SCHEMBL19841032 | 0.82 | NPC1 (0.40) | EPHX2MEN1KMT2AMAPTPOLB | |
| SCHEMBL19841109 | 0.81 | HSP90AA1 (0.33) | SMN1; SMN2 | |
| SCHEMBL19841076 | 0.81 | RAB9A (0.38) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL19840998 | 0.79 | SMN1; SMN2 (0.37) | NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL19841112 | 0.79 | MAPT (0.38) | EPHX2MEN1KMT2AMAPTPOLB | |
| SCHEMBL19840820 | 0.78 | MAPT (0.39) | MEN1KMT2AMAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884832-B2 | Inhibitors targeting drug-resistant influenza A | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2018-02-06 | — | — | US | disclosed |