Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 0.60 |
| ▸ | SULT1A1 | P50225 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.50 |
| ▸ | RELA | Q04206 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MGAM | O43451 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29787 | 0.90 | MAPT (0.52) | APPSULT1A1MAPTKDM4ERAB9A | |
| SCHEMBL1984152 | 0.87 | MAPT (0.59) | APPMAPTKDM4ERAB9ALMNA | |
| SCHEMBL1984490 | 0.84 | APP (0.61) | APPSULT1A1KDM4ERAB9ANPC1 | |
| SCHEMBL1987630 | 0.82 | CA1 (0.52) | APPMAPTKDM4ERAB9ALMNA | |
| SCHEMBL3237813 | 0.78 | APP (0.71) | APPSULT1A1MAPTKDM4ERAB9A | |
| SCHEMBL5423269 | 0.78 | APP (0.81) | APPSULT1A1MAPTKDM4ERAB9A | |
| SCHEMBL5027039 | 0.77 | MAPT (0.63) | APPMAPTKDM4ERAB9ALMNA | |
| SCHEMBL1988207 | 0.77 | CHEK1 (0.46) | APPMAPTKDM4ERAB9ANPC1 | |
| SCHEMBL5768391 | 0.77 | MAPT (0.57) | APPMAPTKDM4ERAB9ALMNA | |
| SCHEMBL14157073 | 0.76 | APP (0.68) | APPSULT1A1MAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338059-A1 | LIGANDS FOR AGGREGATED TAU MOLECULES | Wista Laboratories Ltd. (SG) | 2011-06-29 | — | — | EP | disclosed |