Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 8/20 | 0.51 |
| ▸ | SULT1A1 | P50225 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984366 | 0.90 | APP (0.60) | MAPTKDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL5768391 | 0.86 | MAPT (0.57) | MAPTKDM4ENPC1RAB9AAPP | |
| SCHEMBL5027039 | 0.84 | MAPT (0.63) | MAPTKDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL11808220 | 0.83 | SULT1A1 (0.52) | MAPTKDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL30810246 | 0.82 | EPHX2 (0.50) | MAPTKDM4ENPSR1DYRK1A | |
| SCHEMBL5177282 | 0.81 | ILK (0.57) | MAPTNPC1RAB9ANPSR1APP | |
| Hydrochloric Acid SCHEMBL30810214 | 0.81 | EPHX2 (0.49) | MAPTKDM4ENPSR1DYRK1A | |
| SCHEMBL27648807 | 0.80 | MAPT (0.67) | MAPTKDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL5416207 | 0.80 | MAPT (0.69) | MAPTKDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL27714785 | 0.78 | MAPT (0.56) | MAPTKDM4ENPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |