Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.65 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31037156 | 1.00 | CHRNB2 (0.65) | CHRNB2CHRNA4KEAP1NFE2L2MEN1 | |
| Ammonia Solution, Strong SCHEMBL3031537 | 0.98 | CHRNB2 (0.63) | CHRNB2CHRNA4KEAP1NFE2L2MEN1 | |
| Cyanide SCHEMBL27784387 | 0.95 | CHRNB2 (0.60) | CHRNB2CHRNA4KEAP1NFE2L2MEN1 | |
| SCHEMBL1008449 | 0.87 | CHRNB2 (0.58) | CHRNB2CHRNA4KEAP1NFE2L2MEN1 | |
| SCHEMBL2374109 | 0.86 | CHRNB2 (0.70) | CHRNB2CHRNA4MEN1KMT2AMAPT | |
| SCHEMBL29547480 | 0.85 | CHRNB2 (0.65) | CHRNB2CHRNA4KEAP1NFE2L2MEN1 | |
| SCHEMBL15498199 | 0.85 | CHRNB2 (0.73) | CHRNB2CHRNA4MEN1KMT2AMAPT | |
| SCHEMBL16178929 | 0.85 | CHRNB2 (0.64) | CHRNB2CHRNA4MAPTLMNATSHR | |
| SCHEMBL17905717 | 0.85 | CHRNB2 (0.68) | CHRNB2CHRNA4MEN1KMT2AMAPT | |
| SCHEMBL9795648 | 0.84 | CHRNB2 (0.63) | CHRNB2CHRNA4MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037303-B2 | Method for preparing diaryl p-phenylenediamine compounds | SENNICS CO., LTD. (CN) | 2024-07-16 | — | — | US | claimed |
| US-20240076264-A1 | METHOD FOR PREPARING DIARYL P-PHENYLENEDIAMINE COMPOUNDS | SENNICS CO., LTD. (CN) | 2024-03-07 | — | — | US | claimed |
| CN-1539821-A | Molecule material of teera aryl aether pentacites | 复旦大学 | 2004-10-27 | — | — | CN | claimed |
| US-4473713-A | Hydrolysis of aryl-aliphatic ethers | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-09-25 | — | — | US | claimed |
| US-12037303-B2 | Method for preparing diaryl p-phenylenediamine compounds | SENNICS CO., LTD. (CN) | 2024-07-16 | — | — | US | disclosed |
| US-20240076264-A1 | METHOD FOR PREPARING DIARYL P-PHENYLENEDIAMINE COMPOUNDS | SENNICS CO., LTD. (CN) | 2024-03-07 | — | — | US | disclosed |
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |
| US-20200163964-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | AUTIFONY THERAPEUTICS LIMITED (GB) | 2020-05-28 | — | — | US | disclosed |
| US-10632118-B2 | Imidazolidinedione derivatives | AUTIFONY THERAPEUTICS LIMITED (GB) | 2020-04-28 | — | — | US | disclosed |
| EP-2389352-B1 | ARGINASE INHIBITORS AND METHODS OF USE | UNIV PENNSYLVANIA (US) | 2019-05-08 | — | — | EP | disclosed |
| US-20180021336-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | AUTIFONY THERAPEUTICS LIMITED (GB) | 2018-01-25 | — | — | US | disclosed |
| US-20180021336-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | AUTIFONY THERAPEUTICS LIMITED (GB) | 2018-01-25 | — | — | US | disclosed |
| WO-2000013794-A1 | POLYMERIC SUPPORTED CATALYST COMPRISING A WATER-SOLUBLE TRANSITION METAL COMPLEX | BASF AKTIENGESELLSCHAFT (DE) | 2000-03-16 | — | — | WO | disclosed |
| EP-0518151-B1 | Process for the preparation of nitrophenyl-alkylethers | BAYER AG (DE) | 1995-09-06 | — | — | EP | disclosed |
| US-5399773-A | Process for the preparation of nitrophenyl alkyl ethers | BAYER AKTIENGESELLSCHAFT (DE) | 1995-03-21 | — | — | US | disclosed |
| EP-0518151-A1 | Process for the preparation of nitrophenyl-alkylethers | BAYER AG (DE) | 1992-12-16 | — | — | EP | disclosed |
| US-4473713-A | Hydrolysis of aryl-aliphatic ethers | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-09-25 | — | — | US | disclosed |
| US-4127728-A | FRIEDEL-CRAFTS CATALYST | BAYER AKTIENGESELLSCHAFT (DE) | 1978-11-28 | — | — | US | disclosed |
| US-4044049-A | Phenyl benzoic acid compounds | MERCK & CO., INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3963698-A | Alkylations employing in situ generation of diazoalkane alkylation reagents | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1976-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021336-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | KCND3, KCNK3, KCNA3 | CHRNB2 275/4885CHRNA4 99/4885KEAP1 3193/4885 |
| US-10632118-B2 | Imidazolidinedione derivatives | KCND3, KCNK3, KCNA3 | CHRNB2 275/4885CHRNA4 99/4885KEAP1 3193/4885 |
| US-20240076264-A1 | METHOD FOR PREPARING DIARYL P-PHENYLENEDIAMINE COMPOUNDS | C9, C1S, CCND2 | CHRNB2 2058/4885CHRNA4 2205/4885KEAP1 242/4885 |
| US-20200163964-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | KCND3, KCNK3, KCNA3 | CHRNB2 275/4885CHRNA4 99/4885KEAP1 3193/4885 |
| US-12037303-B2 | Method for preparing diaryl p-phenylenediamine compounds | C9, C1S, CCND2 | CHRNB2 2058/4885CHRNA4 2205/4885KEAP1 242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.